"Permanent His bundle pacing has been around for almost 20 years, but until now there hasn't been randomized clinical trials on how it compares to biventricular pacing," Tung said.įor the His SYNC trial, all of the patients met the current guidelines for receiving cardiac resynchronization therapy and were randomly selected to receive either a His bundle pacer or a coronary sinus lead for biventricular pacing. The latter involves implanting a single lead at the start of the heart's wiring system, which then naturally branches in two to organically distribute the pacemaker's electric pulse to both ventricles.
#Ivcd heart trial
Tung's team looked to see if another resynchronization method could help reduce that number by doing a clinical trial comparison between biventricular pacing and His bundle pacing. Nevertheless, roughly 30 percent of patients do not respond to biventricular pacing treatment, which has been shown to improve survival in clinical trials. A pacemaker then sends a timed electric pulse to the two leads with the goal of a synchronized contraction, which closely simulates the heart's natural heartbeat.
The study was also published in the Journal of the American College of Cardiology.īiventricular pacing involves implanting wires, called leads, to simultaneously pace the right and left ventricles of the heart.
To qualify as a late-breaking trial, the research must be groundbreaking and unique. Results of the study were presented as a featured late-breaking trial at the Heart Rhythm Society's annual scientific sessions in San Francisco on May 9. The UChicago Medicine team served as the independent coordinating site. The trial involved 40 adult patients across seven institutions in the Midwest. Tung spearheaded the two-year trial with UChicago Medicine cardiologist Gaurav Upadhyay, MD, FHRS, lead author of the study. Previously, we have just accepted that we had to bypass it through pacing two ventricles at a time." "Through His bundle pacing, we're trying to tap into the normal wiring of the heart and restore conduction the way nature intended. "This is the first prospective study in our field to compare outcomes between different ways to achieve cardiac resynchronization," said cardiologist Roderick Tung, MD, FHRS, the Director of Cardiac Electrophysiology & EP Laboratories at the University of Chicago Medicine. The two approaches have never before been directly compared in a head-to-head clinical trial. The current standard of care, known as biventricular pacing, uses two pacing impulses in both lower chambers, whereas the newer approach, called His bundle pacing, attempts to work toward engaging and restoring the heart's natural physiology. In a first-ever pilot study, called the His SYNC trial, researchers compared the effectiveness of two different cardiac resynchronization therapies, or treatments to correct irregularities in the heartbeat through implanted pacemakers and defibrillators.
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